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Concomitant use or discontinuation of CYP450 isoenzymes which includes CYP450 3A4 inducers, CYP450 3A4 inhibitors, or CYP450 2D6 inhibitors are advanced; concomitant use calls for careful consideration of the results over the mum or dad drug, tramadol, plus the active metabolite, M1.When an opioid analgesic is getting discontinued on account of a s
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